Fan et al. describe a microfluidic chip for multiplexed analysis of proteins in a finger prick of blood. The chip separates plasma from diluted whole blood and quantifies panels of serum proteins in ~10 minutes, minimizing protein degradation.

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Fruit-specific overexpression of a pair of snapdragon transcription factors produces tomatoes that uniformly accumulate anthocyanins at levels unprecedented for metabolic engineering. When included as a dietary supplement, the purple tomatoes increase the life spans of tumorigenic p53 knockout mice.

Chechik et al. define activity motifs, which extend the concept of a network motif from the static to the dynamic realm. Mapping functional data onto network structure enables them to reveal new systems-level principles describing how yeast cells integrate exogenous signals and use transcriptional regulation to optimize metabolic responses to environmental perturbations.