Nature Genetics - Current issue : November 2008 - Vol 40 No 11
Latest highlights
Advance online publication
Two groups, led by Sudipto Roy and Chris Kintner, report that the transcription factor Foxj1 is sufficient to induce ectopic formation of motile cilia by upregulating expression of genes encoding key components of the motile ciliary machinery.
Advance online publication
Colorectal cancer associations
Article by Richard HoulstonRichard Houlston and colleagues identify four new susceptibility loci for colorectal cancer through a meta-analysis of genome-wide association data, followed by replication testing in a large collection of independent samples.
Advance online publication
Risk of intracranial aneurysm
Letter by Kaya BilguvarRichard Lifton and colleagues report the identification of three susceptibility loci for intracranial aneurysm. Two of the loci are new, with SNPs on chromosome 8q likely acting through SOX17, which is required for the formation and maintenance of endothelial cells.
Advance online publication
KIF1B and multiple sclerosis
Brief Communication by Yurii AulchenkoRogier Hintzen and colleagues report the results of a search for variants associated with susceptibility to multiple sclerosis. They identify a new risk variant in KIF1B, which is expressed in motor neurons and is involved in axonal transport.
Poster and podcast
Next-generation sequencing technologies
Nature Genetics and Nature Reviews Genetics present a poster and podcast that explore the conceptual basis of next-generation sequencing technologies, their myriad applications and the challenges for the future. Access to both is free, thanks to support from Applied Biosystems.
Conference
Mitochondrial Dysfunction in Neurological Disease
ConferenceIn collaboration with Nature Neuroscience and the Fondation IPSEN, we are pleased to announce a one-day symposium on mitochondrial dysfunction in neurological disease, to be held in Durham, North Carolina on December 5. The meeting aims to bring together geneticists, neuroscientists and cell biologists to highlight recent advances in this field.
